The Relationship between Plasma Visfatin/Nampt and Type 2 Diabetes, Obesity, Insulin Resistance, and Cardiovascular Disease
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چکیده
Submit Manuscript | http://medcraveonline.com Abbrevations: PBEF: Pre-B cell colony Enhancing Factor; NAD: Nicotinamide Adenine Dinucleotide; Sir2: Silent information regulator 2; NMN: Nicotinamide Mononucleotide; GLP-1: Glucagon Like Peptide-1; SAT: Subcutaneous Adipose Tissue; VAT: Visceral Adipose Tissue; FSIGT: Frequently Sampled Intravenous Glucose Tolerance; IMCL: Intramyocellular Lipid; mPTP: mitochondrial Permeability Transition Pore; HCAECs: Human Coronary Artery Endothelial Cells; NF: Nuclear Factor
منابع مشابه
Relationship Between Cerebrospinal Fluid Visfatin (PBEF/Nampt) Levels and Adiposity in Humans
OBJECTIVE Observations of elevated circulating concentrations of visfatin (PBEF/Nampt) in obesity and diabetes suggest that this recently described adipokine is involved in the regulation of body weight and metabolism. We examined in humans whether visfatin is found in cerebrospinal fluid (CSF) and, if so, how CSF visfatin concentrations relate to adiposity and metabolic parameters. RESEARCH ...
متن کاملSensitive detection of Nampt(PBEF/Visfatin) in human serum for Point-Of-Care applications using aptamer based capacitive biosensor
limiting intracellular enzyme for nicotinamide adenine dinucleotide (NAD) synthesis starting from nicotinamide [1]. The plasma Nampt levels are reported to have correlation with obesity and obese related metabolic disease, such as Type 2 diabetes mellitus (T2DM), cardiovascular diseases [2] and hyperlipidemia [3] due to association with lipoprotein and cholesterol. Therefore, sensitive detectio...
متن کاملGenetic variation in the visfatin (PBEF1/NAMPT) gene and type 2 diabetes in the Greek population.
Visfatin (NAMPT formerly known as PBEF1) is an adipokine that is strongly expressed in visceral fat and has caused much debate among researchers, regarding its involvement in glucose homeostasis and insulin resistance. It was initially isolated from bone marrow cells, and its involvement in inflammatory procedures such as sepsis and acute lung inflammation is now evident. Several studies have a...
متن کاملتغییرات ویسفاتین پلاسما و مقاومت به انسولین نوجوانان غیرورزشکار دارای اضافه وزن و چاق در طول 8 هفته تمرین استقامتی تناوبی طناب زنی
Background and Objective: Visfatin is a secreted protein from visceral adipose tissue that has been linked to obesity and associated with health risk factors. The purpose of this study was to examine the effects of 8 weeks of interval endurance rope training on plasma visfatin and insulin resistance in overweight non-athletic adolescents. Materials and Methods: In this semi-experimental study, ...
متن کاملسطح پلاسمایی ویسفاتین زنان مبتلا به دیابت نوع 2: مقایسه اثر دو نوع پروتکل تمرینی هوازی و مقاومتی
Introduction : visfatin is a protein with insulin-like functions that secretes from adipose tissue and has been linked to obesity and insulin resistance, but the effect of exercise training on visfatin levels is unknown. The purpose of study was to compare the effect of aerobic and resistance training on plasma visfatin levels in type 2 diabetic women. Material and Methods : 45 women with...
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